Multivalent ligand–receptor interactions elicit inverse agonist activity of AT1 receptor blockers against stretch-induced AT1 receptor activation

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

AT1-receptor blockers

finding of elevated leptin levels in cardiac failure patients stage NYHA II or III is supported by Filippatos et al. and others. From their data, however, it appears that leptin levels tend to decrease in cachectic patients with more advanced stages of the disease, which has only recently been confirmed by others. This does not necessarily contradict our observations. The patients reported in o...

متن کامل

AT1 receptor blockers for cognition decline after cardiac surgery?

AT1 Receptor Blockers for Cognition Decline After Cardiac Surgery? To the Editor: We read with interest the review article on stroke and encephalopathy after cardiac surgery1 and the related editorial.2 We agree that assessing these complications provides a unique clinical opportunity for evaluating preventive strategies because patients at higher risk can be identified before surgery. We would...

متن کامل

Autoantibody against AT1 receptor from preeclamptic patients induces vasoconstriction through angiotensin receptor activation.

Preeclampsia is a serious pathologic complication during pregnancy, and its pathogenesis remains poorly understood. Recent studies have demonstrated that autoantibodies against angiotensin II type 1A receptor (AT1-AA) are present in women with preeclampsia. However, their role in the development of hypertension in preeclamptic patients has never been previously investigated. The present study w...

متن کامل

Novel paramagnetic AT1 receptor antagonists.

Novel paramagnetic selective angiotensin AT(1) receptor antagonists (sartans) bearing nitroxides (3, 4) have been prepared and their pharmacology evaluated in vitro as well as in vivo. Compounds 3, 4 proved to be effective sartans with pK(B) estimates in the range 6.2-9.1. In addition, the sodium salt (11) of 4 (R = Bu) is able to protect against vascular injury in hypertensive rats as determin...

متن کامل

Activating autoantibodies against the AT1-receptor in vascular disease

Ralf Dechend1,6, Duska Dragun3, Florian Herse1,2, Gabriele Riemekasten4, Kai Schulze-Forster5, Dominik N. Müller1,2, Harald Heidecke5 1Experimental and Clinical Research Center, Charité, Campus Buch, 2Max-Delbueck Center for Molecular Medicine, 3Department of Nephrology, Charité, Campus Virchow, 4Department of Rheumatology, Charité, Campus Mitte, 5CellTrend, Luckenwalde, 6HELIOS Klinikum Berlin...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Hypertension Research

سال: 2009

ISSN: 0916-9636,1348-4214

DOI: 10.1038/hr.2009.117